Studies on Medicinally Interesting Chemical Entities

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Effect of Planting Density on Growth Parameters and Fruit Yield in Guava (Psidium guajava L.) cv. Allahabad Safeda Cultivated under Mild Humid Conditions of Coorg

A study was carried out in 'Allahabad Safeda' guava (Psidium guajava L.) to standardize the effect of planting densities on growth parameters viz., scion girth, plant height, and spread (East - West and North - South), canopy area, canopy volume and fruit yield over a ten years period. The trial was laid out with five planting densities viz., 6x3, 6x4, 6x6, 8x4, 8x3m accommodating 555, 416, 277, 312 and 416 plants/ha respectively with four replications having sixteen plants per treatment in a randomized block design during 1988-89 season. The grafted plants on seedling rootstock were planted and the yield data were recorded from 1992 to 1997. The results indicated that the scion girth was significantly higher in 8x3 or 8x4m configurations. There were no significant differences among treatments for plant height. The plant spread across East-West direction was however significant in 8x3m. The fruit yield in Mrig bahar was significantly higher as compared to that of Hasth bahar in terms of fruit number and weight. Land Use Index (LUI) values exceeding 50% had bearing on the productivity of different configurations. The productivity was nearly double in 6x3m where, the planting density was twice as much in recommended spacing (6x6m) by sixth year of planting after which, yield levels declined. Thus, it was concluded that a spacing of 6x3m having 555 plants/ha, gives the highest productivity in 'Allahabad Safeda' guava by sixth year of planting under North Coorg conditions

ACCURACY OF FNAC IN FEMALE BREAST LESIONS

Background: Various breast lesions are common lesions in females with a wide range of variability from inflammatory lesions, benign and malignant breast lesions. FNAC is first diagnostic test, as it has high sensitivity and specificity. Lesions were categorized on FNA into inflammatory lesions, benign neoplastic lesions, malignant neoplastic lesions, and suspicious for malignancy. Methods: This was a retrospective study done in the Department of Pathology, P.D.U. Medical College, Rajkot, Gujarat State, India from Aug-2013 to July 2014. FNAC of 392 cases of breast lesions were done and reported by expert pathologist. The histopathological specimens when available were reported by other pathologist without prior knowledge of FNA diagnosis. Sensitivity, Specificity and Accuracy of FNA diagnosis were then analyzed. Results: A total of 392 cases of breast lesions were diagnosed on FNA, out of them histopathological correlation was available in 87 cases. Benign breast lesions are more common in younger patients in 21-30 yrs age group and malignant lesions are more common in old age group patients of 41-60 yrs with few exceptions. In our setup fibroadenoma is the most common benign breast lesion (26.53%) and ductal carcinoma (17.86%) is the most common malignant lesion. The sensitivity, specificity and accuracy of FNAC for malignant lesions were found to be 91.43%, 100% and 96.25% respectively. Conclusion: FNAC is an effective and valid tool as the first line diagnostic modality in the preoperative diagnosis of the malignant and benign breast lesions.KEYWORDS: FNAC; Breast lesions; Fibroadenoma; Ductal carcinoma

ACCURACY OF FNAC IN FEMALE BREAST LESIONS

Background: Various breast lesions are common lesions in females with a wide range of variability from inflammatory lesions, benign and malignant breast lesions. FNAC is first diagnostic test, as it has high sensitivity and specificity. Lesions were categorized on FNA into inflammatory lesions, benign neoplastic lesions, malignant neoplastic lesions, and suspicious for malignancy. Methods: This was a retrospective study done in the Department of Pathology, P.D.U. Medical College, Rajkot, Gujarat State, India from Aug-2013 to July 2014. FNAC of 392 cases of breast lesions were done and reported by expert pathologist. The histopathological specimens when available were reported by other pathologist without prior knowledge of FNA diagnosis. Sensitivity, Specificity and Accuracy of FNA diagnosis were then analyzed. Results: A total of 392 cases of breast lesions were diagnosed on FNA, out of them histopathological correlation was available in 87 cases. Benign breast lesions are more common in younger patients in 21-30 yrs age group and malignant lesions are more common in old age group patients of 41-60 yrs with few exceptions. In our setup fibroadenoma is the most common benign breast lesion (26.53%) and ductal carcinoma (17.86%) is the most common malignant lesion. The sensitivity, specificity and accuracy of FNAC for malignant lesions were found to be 91.43%, 100% and 96.25% respectively. Conclusion: FNAC is an effective and valid tool as the first line diagnostic modality in the preoperative diagnosis of the malignant and benign breast lesions.KEYWORDS: FNAC; Breast lesions; Fibroadenoma; Ductal carcinoma

Evolution of Conversations in the Age of Email Overload

Email is a ubiquitous communications tool in the workplace and plays an important role in social interactions. Previous studies of email were largely based on surveys and limited to relatively small populations of email users within organizations. In this paper, we report results of a large-scale study of more than 2 million users exchanging 16 billion emails over several months. We quantitatively characterize the replying behavior in conversations within pairs of users. In particular, we study the time it takes the user to reply to a received message and the length of the reply sent. We consider a variety of factors that affect the reply time and length, such as the stage of the conversation, user demographics, and use of portable devices. In addition, we study how increasing load affects emailing behavior. We find that as users receive more email messages in a day, they reply to a smaller fraction of them, using shorter replies. However, their responsiveness remains intact, and they may even reply to emails faster. Finally, we predict the time to reply, length of reply, and whether the reply ends a conversation. We demonstrate considerable improvement over the baseline in all three prediction tasks, showing the significant role that the factors that we uncover play, in determining replying behavior. We rank these factors based on their predictive power. Our findings have important implications for understanding human behavior and designing better email management applications for tasks like ranking unread emails.Comment: 11 page, 24th International World Wide Web Conferenc

Spectroscopy of Heavy-Light Mesons (csˉc\bar{s}, cqˉc\bar{q}, bsˉb\bar{s}, bqˉb\bar{q}) for the linear plus modified Yukawa potential using Nikiforov-Uvarov Method

An approximate bound state solution of the Klein-Gordon equation is derive analytically for the 3-dimensional space with a combination framework of linear plus modified Yukawa Potential (LIMYP) using the Nikiforov-Uvarov (N-U) method for obtaining the energy eigenvalues and corresponding wave function. A detailed study of mass spectra of all combination sets of heavy-light flavor mesons vis-a-vis $(Ks/Kq; K= C, B)$ is investigated by treating both heavy-light flavor mesons non-relativistic with an effective quark-antiquark interaction potential for different quantum states. Along with that, an elucidated graphical representation is scrutinized with the calculated mass spectra obtained from the energy eigenvalue against the corresponding variables for all the combination sets of heavy-light flavors mesons. Therefore, the current framework potential provides excellent reconciliation with the experimental data of states known to date and minuscule \% difference in lower quantum states, which increases with higher quantum states that can be correlated with the higher screening factor coming into the account.Comment: 28 pages, 32 figures, 4 table

Bronchodilatory effect of Zingiber officinale Roscoe (ginger) in guinea pigs

Purpose: To determine the bronchodilatory effect of ginger on histamine-induced bronchospasm in guinea pigs. Methods: Thirty-six guinea pigs weighing 400 - 700 g were randomly divided into six groups. Group 1 received distilled water, while group 2 was given formoterol (1.55 μg/kg) + budesonide (0.02 mg/kg). Guinea pigs in groups 3 and 4 were given ginger (350 and 700 mg/kg, respectively), while those in groups 5 and 6 received ginger (350 and 700 mg/kg, respectively) in addition to formoterol (1.55 μg/kg) and budesonide (0.02 mg/kg). Pre-convulsion time and percent protection in each group was calculated. Results: There was statistically significant improvement in pre-convulsion times, with values of 156.64 ± 32.93, 299.33 ± 44.20, and 235.99 ± 34.55 s for groups 2, 5 and 6, respectively (p < 0.01). Moreover, statistically significant protection values of 73 and 68 % were obtained for groups 5 and 6, respectively, relative to normal control (p < 0.01). Conclusion: These results indicate that ginger has promising potential for use as an add-on treatment for bronchospasm. Keywords: Zingiber officinale, Histamine, Asthma, Pre-convulsion tim

Low-supervision urgency detection and transfer in short crisis messages

Humanitarian disasters have been on the rise in recent years due to the effects of climate change and socio-political situations such as the refugee crisis. Technology can be used to best mobilize resources such as food and water in the event of a natural disaster, by semi-automatically flagging tweets and short messages as indicating an urgent need. The problem is challenging not just because of the sparseness of data in the immediate aftermath of a disaster, but because of the varying characteristics of disasters in developing countries (making it difficult to train just one system) and the noise and quirks in social media. In this paper, we present a robust, low-supervision social media urgency system that adapts to arbitrary crises by leveraging both labeled and unlabeled data in an ensemble setting. The system is also able to adapt to new crises where an unlabeled background corpus may not be available yet by utilizing a simple and effective transfer learning methodology. Experimentally, our transfer learning and low-supervision approaches are found to outperform viable baselines with high significance on myriad disaster datasets.Comment: 8 pages, short version published in ASONAM 201

Direct Interaction of Pericentrin with Cytoplasmic Dynein Light Intermediate Chain Contributes to Mitotic Spindle Organization

Pericentrin is a conserved protein of the centrosome involved in microtubule organization. To better understand pericentrin function, we overexpressed the protein in somatic cells and assayed for changes in the composition and function of mitotic spindles and spindle poles. Spindles in pericentrin-overexpressing cells were disorganized and mispositioned, and chromosomes were misaligned and missegregated during cell division, giving rise to aneuploid cells. We unexpectedly found that levels of the molecular motor cytoplasmic dynein were dramatically reduced at spindle poles. Cytoplasmic dynein was diminished at kinetochores also, and the dynein-mediated organization of the Golgi complex was disrupted. Dynein coimmunoprecipitated with overexpressed pericentrin, suggesting that the motor was sequestered in the cytoplasm and was prevented from associating with its cellular targets. Immunoprecipitation of endogenous pericentrin also pulled down cytoplasmic dynein in untransfected cells. To define the basis for this interaction, pericentrin was coexpressed with cytoplasmic dynein heavy (DHCs), intermediate (DICs), and light intermediate (LICs) chains, and the dynamitin and p150Glued subunits of dynactin. Only the LICs coimmunoprecipitated with pericentrin. These results provide the first physiological role for LIC, and they suggest that a pericentrin–dynein interaction in vivo contributes to the assembly, organization, and function of centrosomes and mitotic spindles

A prospective study on feto-maternal outcome in patients with premature rupture of membranes at tertiary care center

Background: PROM is associated with increased risk of chorioamnionitis, unfavorable cervix and dysfunctional labour, increased cesarean rates, postpartum hemorrhage and endometritis in the mother. Possible neonatal outcomes in cases of PROM may include respiratory distress syndrome, hypothermia, hypoglycemia, intraventricular hemorrhage, broncho pulmonary dysplasia etc. Objective of this study the maternal and perinatal outcomes in premature rupture of membranes at term.Methods: This prospective study was done among 100 pregnant women with premature rupture of membranes after 37 completed weeks visited at department of obstetrics & Gynecology in RCSM Hospital, Kolhapur during June 2014 and June 2015. Inclusion Criteria was Gestational  age  of  >37  weeks  confirmed  by  dates,  clinical  examination  or ultrasound, cervical dilatation of <3 cms, Lack of uterine contractions for atleast 1 hour from PROM, Single live pregnancy in vertex presentation and PROM confirmed by Direct visualization or Litmus.Results: Present study found highest number of cases among age group 20-24 years and mean age was 22 years. Almost 70% cases were un-booked. Average duration to PROM to hospital admission was 9.6 hours. Most common maternal outcome was febrile illness Most common perinatal outcome was birth asphyxia and 3 perinatal death.Conclusions: Pregnancies complicated with PROM should have supervised labor preferably in an institution. Management of each case has to be individualised. A combined effort of obstetrician and neonatalogist is necessary. A good neonatal intensive care unit can be instrumental in reducing the perinatal morbidity and mortality